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The Best Probiotic Supplement If You’re Over 40

Remember life in your 20s? You could eat junk food without gaining weight and stay up all night and function just fine the next day. There was “wiggle room” to make some poor choices with a limited effect on your overall health. 

As we age, however, there’s less margin for error. We’re more likely to be on prescription medications for things such as high blood pressure, cardiovascular disease, and diabetes. Our immune system is just not as effective. We can also have a tougher time digesting certain foods, such as wheat and dairy.

In addition, the composition and population of the probiotic bacteria inhabiting your digestive tract changes. The friendly Bifidobacterium, for example, which line the walls of the large intestine (colon) and help ward off invasive harmful bacteria and other microorganisms, naturally decline. 

Over the years, I’ve studied the different strains of probiotics and which ones decline with age. One thing is clear: The perfect probiotic supplement for a 30 year old might not be ideal for someone 40 or older.

As you age, you want to look for a probiotic supplement that does more than support digestion and regularity. You want to look for one that functions as an anti-aging supplement, too—supporting everything from healthy inflammation to immunity.

The Top 3 Anti-Aging Probiotics for Over 40

Here are the top three probiotic strains of probiotics I believe have the most anti-aging benefits.

  • B. lactis Bl-04 helps prevent the toxic effects of wheat gliadin, a component of gluten that becomes a source of problems for many people.
  • B. longum BB-536 has been shown to boost immune function in older adults for as long as 20 weeks, even after they stopped taking the supplement.
  • B. infantis helps to ease inflammation which is linked to everything from pain to heart health.

There are many standard probiotic supplements available to choose from. But if you are 40 or older, make sure your anti-aging supplements contain these three probiotic strains so you can get the important health benefits you need as you age.



Clin Exp Immunol 2008 Jun;152(3):552–8


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